Effects of corneal hydration on corneal biomechanics published in the Journal of Refractive Surgery
Corneal biomechanical properties are most often measured in vitro, however the effect of corneal hydration corneal hydration state, modulated by the storage solutions or postmortem period had never been investigated. In a corneal deformation test with varying intraocular pressure we found that corneal hydration and tissue preservation changed corneal biomechanics, in particular its relaxation over a period of 24 hours. Dehydration by any dextran solution increased the hysteresis after the inflation/deflation cycle Corneas treated with standard cross-linking photosensitizer (riboflavin– dextran) deformed most indicating a softening of the corneal tissue compared to control corneas. The results of high interest in the experimental evaluation of the collagen cross-linking treatment for keratoconus. The results appear in this month’s issue of Journal of Refractive Surgery.