Corneal biomechanical properties from OCT Vibrography published in Journal of the Royal Society Interface
The study demonstrates the use of phase-sensitive OCT in combination with acoustic stimulation to obtain mechanical properties of the cornea. A finite-element model shows that the measured resonance frequency of the vibrating cornea is proportional to corneal elasticity.
The method was demonstrated on corneal flaps and intact corneas. The resonance frequency shifted after a cross-linking corneal stiffening procedure. The study is a collaborative work between the Visual Optics and Biophotonics Lab (Institute of Optics, CSIC) led by Prof. Susana Marcos, and Prof. Andy Yun’s lab at Wellman Center of Photomedicine, Massachusetts General Hospital (Harvard /HSTI-MIT)
Full reference: Sabine Kling, Imran B. Akca, Ernest W. Chang, Giuliano Scarcelli, Nandor Bekesi, Seok-Hyun Yun, and Susana Marcos “Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties” J R Soc Interface 2014 11:20140920; doi:10.1098/rsif.2014.0920