Corneal wound healing following in vivo Rose Bengal-Green Light and Riboflavin-UVA CXL, published in IOVS
A new collaborative study between Universidad de Valladolid Wellman Center of Photomedicine (Harvard-MGH) and VioBio Lab (CSIC) reports corneal would healing changes (corneal and epithelium thickness, cell death and proliferation and differentiation to myofibroblasts following two corneal cross-linking modalities in vivo (0 to 60 days post-surgery). UVX produced deeper and longer-lasting cell damage compared to RGX indicating a slower cell repopulation after UVX and other differences in healing. This additional advantage of RGX adds to previously reported shallower damage and a shorter treatment time and effective stiffening.
The study has been published in the current issue of IOVS.
Full reference: Elvira Lorenzo-Martín; Patricia Gallego-Muñoz; Lucía Ibares-Frías; Susana Marcos; Pablo Pérez-Merino; Itziar Fernández; Irene E. Kochevar; M. Carmen Martínez-García. Rose Bengal and Green Light Versus Riboflavin–UVA Cross-Linking: Corneal Wound Repair Response, Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4821-4830.