2EyesVision, VIOBIO-CSIC Spin-off, announces Venture Capital investment


2Eyes Vision, spin off of the Visual Optics and Biophotonics Laboratory of the Spanish National Research Council (CSIC) has announced today a Series A investment led by Bullnet Capital. The investment will provide the company with the necessary resources to strengthen product development and to create a sales and marketing structure.

The SimVis technology is the result of a 7 year investigation and it allows cataract and presbyopic patients to experience, for the first time, the real world through multifocal corrections before contact lens fitting and intraocular lenses implantation, allowing the ophthalmologist to take a personalized decision on the lens to be implanted based on the patient’s preferences.

Read full press-release here


Quantization of collagen organization in the stroma with a new order coefficient, published in Biomedical Optics Express


A new order coefficient was introduced to quantize the differences in organization between three different types of treatment applied to porcine corneas: untreated corneas, UVX crosslinked corneas, and corneas treated with riboflavin.  Collagen fibers in the stroma were imaged through a depth of 700 mm using forward-scattering second harmonic generation microscopy.  Analysis points based on the orientation of the fibers were calculated and the number of points falling within 10° analysis windows was counted.  From these points, the order coefficient was calculated as the normalized variance of the number of analysis points in each window.  This quantization showed that the UVX crosslinked corneas were more ordered up to a depth of 400 mm in the stroma.

Full reference: James A. Germann, Eduardo Martínez-Enriquez and Susana Marcos. “Quantization of collagen organization in the stroma with a new order coefficient” Biomed. Opt. Express 9, 173-189 (2018).

Full article here.

Welcome to VioBio: Andrea Curatolo


We are pleased to welcome Dr. Andrea Curatolo in VioBio Lab. Andrea is joining from the University of Western Australia in Perth, where he completed his PhD at the Optical & Biomedical Engineering Laboratory under the supervision of Prof. David Sampson, and has been a Senior Research Associate School of Electrical, Electronic and Computer Engineering for around 10 years. His work includes Optical Coherence Tomography, diagnostic imaging systems engineering design, technology development and supervision of endoscopic and interstitial prototypes deployment in clinical settings.

Andrea is originally from Italy, having completed his MSc in 2006 in Physics Engineering at Politecnico di Milano, with a thesis on the development of a portable multispectral imaging system for works of art diagnostics. He attended the first year of his master’s degree at the Institute of Technology (LTH) in Lund, Sweden. At VioBio he will be joining Optical Coherence Tomography project for optical applications. 

Experimental measurement of Longitudinal Chromatic Aberration in patients implanted with trifocal diffractive IOLs, published in JRS


Trifocal diffractive Intraocular Lenses are increasingly popular designs for the correction of Presbyopia. Using a polychromatic Adaptive Optics system we measured chromatic difference of focus at multiple wavelengths (psycophysical and double-pass measurements) and far/intermediate/near foci in 10 patients bilaterally implanted with the FINeVision Trifocal IOL (hydrophilic material) by PhysIOL. Longitudinal Chromatic Aberration was largest for far and close to zero for near vision. Refractive and diffractive effects can be used to modulate chromatic aberration in patients implanted with diffractive IOLs.

The study is the result of collaborative work between VioBio Lab (CSIC) Innova Ocular  and PhysIOL

Full Reference: Maria Vinas, Ana Gonzalez-Ramos, Carlos Dorronsoro, Vyas Akondi, Nuria Garzon, Francisco Poyales, Susana Marcos, . In Vivo Measurement of Longitudinal Chromatic Aberration in Patients Implanted With Trifocal Diffractive Intraocular Lenses Journal of Refractive Surgery. 2017; 33 (11): 736-742

Full article here.

Susana Marcos received Premio Rey Jaime I in “New Technologies” in Award Ceremony



Rey Jaime I Awards Ceremony took place at Lonja de Valencia on October 30 in an event presided by HM Queen Letizia.

Susana Marcos received the New Technologies Award in the 29th edition of these awards that highlight the work of Spanish researchers and entrepreneurs. The jury for the New Technologies category, which included four Nobel Prize winners, unanimously decided to award Susana Marcos for “her important contributions to the field of physics of vision and, in particular, her studies on imaging and ocular diagnostics that had led to the development of new intraocular lenses and the detection of ocular diseases”.

More information:

Role of parafovea in blur perception published in Vision Research


The blur experienced by our visual system is not uniform across the visual field. Additionally, lens designs with variable power profile such as contact lenses used in presbyopia correction and to control myopia progression create variable blur from the fovea to the periphery. We studied the perceived neutral focus with images of different angular subtense (from 4° to 20°) and found that the amount of blur, for which focus is perceived as neutral, increases with stimulus size. We also studied the changes in central perceived neutral focus after adaptation to images with similar magnitude of optical blur across the image or varying blur from center to the periphery. Altering the blur in the periphery had little or no effect on the shift of perceived neutral focus following adaptation to normal/blurred central images. These perceptual outcomes should be considered while designing bifocal optical solutions for myopia or presbyopia.

The study is a result of collaborative work between the Department of Applied Physics, KTH, Royal Institute of Technology and VioBio Lab, Instituto de Optica CSIC, in the context of Marie Curie ITN Opal.

The results are published in Vision Research: A. Venkatamaran, A. Radhakrishan, C. Dorronsoro, L. Lundström & S. Marcos, “Role of Parafovea in blur perception”, Vision Research 138, 59-65 (2017).

Full article here.

SimVis Patent awarded Best Patent of the Year by Fundación Madri+d


Congratulations to Carlos Dorronsoro, José Ramón Alonso and Susana Marcos, inventors of Patent “Miniaturized Simultaneous Vision Simulator”, which has been awarded with the Best Patent Award by Fundación Madrid+d. The jury has positively evaluated the large market potential for a device that addresses the aging of the population. The patent, along two others owned by CSIC, and licensed to the spin-off company 2EyesVision, is the core technology of SimVis, a wearable see-through simulator of multifocal corrections for presbyopia.

– Press release by Fundación Madri+d 

– Press release by CSIC.

– More information about the patent’s technology here

Spin-off 2EyesVision showcasts SimVis Technology at ESCRS Exhibit


2EyesVision, a spin-off of CSIC founded by VIOBIO Lab members was present at the European Society of Cataract and Refractive Surgery Exhibit with a booth showcasting SimVis technology. Hundreds of delegates could experience multifocality with SimVis wearable, bifocal, programmable, see-through device.

More information on 2EyesVision and SimVis:


Sara El Aissati granted FPU to follow PhD work in VioBio Lab

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Congratulations to Sara El Aissati, winner of a Predoctoral Fellowship of the highly competitive program FPU (Formacion Personal Universitario) from the Spanish Government (Ministry of Education). She will be investigating the use of different adaptive optics technologies to simulate presbyopic corrections.

More information of FPU Program: https://www.mecd.gob.es/servicios-al-ciudadano-mecd/catalogo/general/educacion/998758/ficha/998758-2016.html

Alberto de Castro, COFUND Multiply Postdoctoral Fellow joins VIOBIO Lab



We welcome Dr. Alberto de Castro who joins the Visual Optics and Biophotonics Lab under the Marie Curie COFUND Action MULTIPLY.

Alberto de Castro developed his PhD thesis at the Institute of Optics under the supervision of Prof. Susana Marcos presenting the first estimates 3-D Gradient Index profiles of human crystalline lenses, based on OCT, for which he received the PhD thesis extraordinary Award from the University of Valladolid. He joins VioBio after several years of postdoctoral training in Indiana University (Steve Burns’ Laboratory) and Universidad de Murcia (Pablo Artal’s Lab) where he has worked on high resolution ocular imaging. His COFUND MULTIPLY project combines sophisticated ocular imaging and intraocular lens design.

COFUND MULTIPLY Program is an International Mobility and Training Program in Photonics for Experienced Researchers coordinated by Aston University. The Institute of Optics (CSIC) is one of the partners of the international research consortium.

More information about Multiply: http://multiply.astonphotonics.uk/

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