Monthly Archives: April 2017

New in the lab: Sara El Aissati and Ana María Gonzalez-Ramos

Sin título

We welcome Sara El Aissati and Ana María Gonzalez-Ramos to VioBio Lab. Sara El Aissati has a degree in Optometry (2015) and a Masters in Optical Technologies by Universidad Complutense de Madrid.  Ana María Gonzalez-Ramos holds a BSc in Optometry (2015) and a MSc in Optical Technologies by Universidad Complutense de Madrid.  They are joining the VioBio Lab under the Comunidad de Madrid Youth Guarantee Program and will be working in the fields of adaptive optics visual simulations and characterization of the optical quality of the eye with contact and intraocular lenses.

More information about  Youth Guarantee Program in the following links:


New in the lab: Elena Rico


We welcome Elena Rico in VioBio Lab, joining as Project Assistant. Elena holds a BSc in Biology by Universidad Autónoma de Madrid and a MSc in Biotechnology by Aliter International Business School. Elena worked as project assistant in the European Project IS IT GREEN (Lifelong Learning Programme) and in the Madrid Biotechnology Companies Association (BioMadrid), where she gained experience in management and institutional relations.  

VioBio Lab offers two CSIC JAE Intro Fellowships in Visual Optics and Biophotonics



CSIC has launched the JAE Intro Program, a 2-month fellowship program for Master students to gain experience in research environments.

VioBio Lab (Instituto de Óptica) will host 2 of the 100 offered fellowships, to work on Adaptive Optics Visual Simulations and High Resolution Imaging in the eye. Candidates need to have a degree in Physics, Engineering and/or Optics, a competitive CV (>7/10 average score), and a motivation to enroll in a dynamic multidisciplinary research program. Deadline for applications is May 9. The expected starting date is Sept-Oct 2017.

Reference code for the fellowships are:



Full information on the program can be found in:
Documents in English include the Summary of the call and FAQ

Interested candidates can apply directly through CSIC webpage. We recommend that candidates communicate motivation/intention by emailing


Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens published in Journal of Refractive Surgery


Is it possible to separate the wavefront aberrations of the eye from the multifocal intraocular lens pupillary power distribution after a cataract surgery? Our recent paper answers this question using OCT and LRT measurements in the case of a commercially available rotationally asymmetric segmented refractive multifocal intraocular lens, Lentis Mplus (Oculentis GmbH, Berlin, Germany). Custom analysis of ray tracing–based retinal spot diagrams allowed decoupling of the true higher order aberrations of the patient’s eye from the power pupillary distribution of the Lentis Mplus IOL, therefore providing the appropriate phase map to accurately evaluate through-focus optical quality. The method was tested using ray tracing optical simulations in a computer eye model virtually implanted with the Lentis Mplus IOL, with a generic cornea or with anterior segment geometry obtained from custom quantitative spectral-domain optical coherence tomography in a real patient. The method was applied to laser ray tracing aberrometry data at near and far fixation obtained in a patient implanted with the Lentis Mplus IOL.

Full reference: Akondi V, Pérez-Merino P, Martinez-Enriquez E, Dorronsoro C, Alejandre N, Jiménez-Alfaro I, Marcos S. Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens. J Refract Surg. 2017; 33(4): 257-265. doi: 10.3928/1081597X-20161206-03

Full article:

VioBio Lab at ARVO 2017


VioBio Lab will be present at the Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting in Baltimore (May 6-11) with 10 oral presentations and posters. Topics span: Corneal biomechanics, cross-linking, crystalline lens geometry, animal models for myopia, cataract surgery, multifocal lens simulation, chromatic aberration and accommodating IOLs.

You can find our ARVO planner itinerary in this link: VioBio ARVO Schedule

Comparison of vision through surface modulated and spatial light modulated multifocal optics published in Biomedical Optics Express

Sin título

Spatial-light-modulators (SLM) are increasingly used as active elements in adaptive optics (AO) systems to simulate optical corrections, in particular multifocal presbyopic corrections. In this study, we compared perceived visual quality with lathe-manufactured multi-zone multifocal segmented surfaces and through the same corrections simulated with a SLM in a custom-developed two-active-element AO visual simulator, and found high correspondence between them. Moreover, optical simulations predicted differences in perceived visual quality across different designs.

Full reference: Maria Vinas, Carlos Dorronsoro, Aiswaryah Radhakrishnan, Clara Benedi-García, Edward Anthony LaVilla, Jim Schwiegerling, and Susana Marcos, “Comparison of vision through surface modulated and spatial light modulated multifocal optics,” Biomed. Opt. Express 8, 2055-2068 (2017).

Biomechanical Changes After In Vivo Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA published in IOVS


Biomechanical properties of in vivo CXL rabbit corneas with two different CXL modalities were evaluated one and two months after treatments by Corvis ST air puff dynamic Scheimpflug imaging. The material properties were determined by inverse finite element analysis. Results show that CXL has higher effect after two months than one month for both CXL modalities, but it is still lower than values immediately after the treatment.

Full reference: Nandor Bekesi, Patricia Gallego-Muñoz, Lucía Ibarés-Frías, Pablo Perez-Merino, M. Carmen Martinez-Garcia, Irene E. Kochevar, Susana Marcos. “Biomechanical Changes After In Vivo Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA”. Invest. Ophthalmol. Vis. Sci. 2017;58(3):1612-1620 (2017).

Full article: 


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