VioBio Lab presence at BER 2023

Biophotonics for Eye Research Summer School (BER2023) took place at the University Residence of Jaca (University of Zaragoza) this weekend. The meeting, organized by Spanish Optical Society (SEDOPTICA), included master classes, invited talks and social events. The main goal was the interaction between basic science and the latest technological developments to solve problems on vision physics and to promote potential relationships between research groups in Biophotonics, Visual and Biomedical Optics.

Check out VioBio Lab’s contributions: 

Friday June 2nd

11:50 – 12:10h. Judith S. Birkenfeld. Optical Coherence Tomography for the investigation of ocular biomechanics: An overview of different excitation methods and their applications. Invited talk.

15:30 – 15:50h. María Viñas-Peña. Investigating the ocular optics, biomechanics and structure using light based technologies. Invited talk.

15:50 – 16:10h. James A. Germann. Multi-Photon Microscopy: How the microscale affects the macro-world. Invited talk.

Saturday June 3d

 9:20 – 9:40h. Carlos Dorronsoro. Simulation and validation of multifocal lenses with SimVis technology. Invited talk. 

Sunday June 4th

9 – 10:30h. Eduardo Esteban-Ibañez. Clinical validation of daily soft multifocal contact lens simulations using SimVis Gekko based on in-vitro measurements. Paper session.

10:30-12h. Victor Rodríguez-López. Direct Subjective Refraction: a new approach for refractive error measurements and the impact of accommodation. Poster session.

10:30-12h. María Pilar Urizar. Towards a low-cost optical biometer: development of a low-cost optical delay line for axial scans and a whole-eye beam scanner for fixation checks. Poster session.

10:30-12h. Amal Zaytouny. Clinical validations of the SimVis binocular visual simulator. Poster session.

Full BER 2023 program here

PhD Thesis Defense by Shrilekha Vedhakrishnan on May 18th 2023

VioBio Lab member Shrilekha Vedhakrishnan will be defending her PhD thesis entitled “Coupling of Multifocal Contact Lens Designs with the Eye’s Optics: Impact on Vision” (PhD supervisors: Susana Marcos & Maria Viñas). The defense will take place tomorrow May 18 at 3pm (CET) at Complutense University of Madrid (Facultad de Óptica y Óptometría, Salón de actos) and can also be followed remotely through the Google Meet Platform: https://meet.google.com/ppb-njtg-aii

VioBio Lab at ARVO 2023 Annual Meeting

You can now check VioBio Lab contributions to ARVO 2023 Annual Meeting on corneal and scleral biomechanics, OCT, corneal epithelial wound repair, crosslinking, crystalline lens accomodation, adaptive optics simulators, direct subjective refraction, etc. and include them in your ARVO itinerary.

Monday, April 24

– Mar Fernandez-Gutierrez, R Gutierrez Contreras, Paula Olalla, Andres De la Hoz, Eduardo Ontoria, Patricia Gallego-Muñoz, Maria del Carmen Martinez, Susana Marcos
Presentation Type: Paper Session (Presentation Number: 1883)
Presentation Title: Growth-factor controlled release in silk fibroin-based corneal bandages
Session Date/Times: April 24, 2023 from 4:30 – 4:45 PM (Central)

Tuesday, April 25

– Eduardo Martinez-Enriquez, Yue Zhao, Derick Ansah, Ugur Celik, Alberto de Castro, Scott MacRae, Mujdat Cetin, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: B0017)
Presentation Title: Estimation of the intraocular lens position from clinical OCT 3-D biometry and machine learning algorithms
Session Date/Times: April 25, 8:45 – 10:30 AM (Central)

– Rocio Gutierrez-Contreras, Patricia Gallego-Muñoz, Andres De la Hoz, Mar Fernandez-Gutierrez, Paula Olalla, Eduardo Ontoria, Maria del Carmen Martinez, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: C0278)
Presentation Title: Demonstration of sutureless fixation of silk fibroin based corneal bandages ex vivo and in vivo
Session Date/Times: April 25, 11:45 AM to 1:30 PM (Central)

– James Germann, Lupe Villegas, Luis Revuelta, Susana Marcos
Presentation Type: Paper Session (Presentation Number: 2859)
Presentation Title: Effects of pharmacological treatments of myopia on scleral collagen organization in myopic guinea pig models
Session Date/Times: April 25, 12:30 – 12:45 PM (Central)

– Victor Rodríguez-Lopez, Cristina Sanchez-Garcia, Eduardo Esteban-Ibañez, Nerea Arejita, Carlos Dorronsoro
Presentation Type: Paper Session (Presentation Number: 2883)
Presentation Title: Robustness of the Direct Subjective Refraction method
Session Date/Times: April 25, 12:00 – 12:15 PM (Central)

– Maria Vinas-Pena, Sangyeon Cho, Yoonha Hwang, Seok-Hyun Yun
Presentation Type: Poster Session (Posterboard Number: B0079)
Presentation Title: Fluorescence lifetimes of scleral tissues after riboflavin-mediated crosslinking
Session Date/Times: April 25, 3:30 PM -5:15 PM (Central)

Wednesday, April 26

– Andrés de la Hoz, Eduardo Martínez-Enríquez, Susana Marcos
Presentation Type: Paper Session (Presentation Number: 3814)
Presentation Title: Patient-customized modeling of crystalline lens accommodation and material properties
Session Date/Times: April 26, 10:45 AM to 11:00 AM (Central)

– Maria del Carmen Martinez, Patricia Gallego-Muñoz, Eduardo Ontoria, Rocío Gutiérrez-Contreras, M. Mar Fernández Gutiérrez, Paula Olalla, Andres De la Hoz, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: C0055)
Presentation Title: Human corneal stromal cells response to silk fibroin-based membranes cross-linked with polyethylene-glycol.
Session Date/Times: April 26, 2:15 – 4:00 PM (Central)

– Fernando Zvietcovich, Judith Birkenfeld, Alejandra Varea, Nicolas Alejandre-Alba, Jesus Merayo-Lloves, Susana Marcos
Presentation Type: Paper Session (Presentation Number: 4390)
Presentation Title: Human cornea biomechanics and subclinical keratoconus detection using ultrasonic wave-based optical coherence elastography
Session Date/Times: April 26, 3:15 – 3:30 PM (Central)

Thursday, April 27

– Alberto de Castro, Eduardo Martinez-Enriquez, Bianca Maceo Heilman, Marco Ruggeri, Ramya Natarajan, Ashik Mohamed, Fabrice Manns, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: C0163)
Presentation Title: Human crystalline lens refractive index distribution: age-related changes consistent with optical behavior
Session Date/Times: April 27, 8 – 9:45 AM (Central)

– Lupe Villegas, Maria Pilar Urizar, Fernando Zvietcovich, Paula Olalla, Alberto de Castro, Andrea Curatolo, Luis Revuelta, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: C0143)
Presentation Title: Myopia control by atropine and latanoprost in a guinea pig model: impact on refraction, biometry and scleral mechanics
Session Date/Times: April 27, 8 – 9:45 AM (Central)

– Alejandra Varea, Fernando Zvietcovich, Judith Birkenfeld, Jesus Merayo-Lloves, Susana Marcos
Presentation Type: Poster Session (Posterboard Number: B0117)
Presentation Title: Changes in corneal biomechanical properties in LASIK refractive surgery patients
Session Date/Times: April 27, 8 – 9:45 AM (Central)

– Amal Zaytouny, Irene Sisó-Fuertes, Xoana Barcala, Lucie Sawides, Carlos Dorronsoro, Susana Marcos
Presentation Type: Paper Session (Presentation Number: 5421)
Presentation Title: Clinical validation of simulated multifocal intraocular lenses. SimVis GekkoTM simulations and reports on pseudophakic patients
Session Date/Times: April 27, 1:15 – 1:30 PM (Central)

New in the lab: Paulina Dotor

We welcome Paulina Dotor, MsC Imaging and Optical Technology by Complutense University of Madrid, who has recently joined VioBio Lab within the framework of CaixaResearch Validate project funded by La Caixa Foundation to promote innovation in healthcare.

Paulina has previous experience working as Clinical Optometrist in Indizen Optical Technologies where she was involved in patient care, generation of visual tests in clinical studies for the development of new products, development of clinical protocols, and quality control of ophthalmic lenses. She will work in the project Direct Subjective Refraction, a new method for estimating visual prescription, in the development of protocols and organization and performance of clinical measurements with the new clinical method.

PhD Thesis Defense by Carmen M. Lago on March 23 2023

VioBio Lab member Carmen M. Lago will be defending her PhD thesis entitled “Development of new applications of simultaneous vision simulator” (PhD supervisors: Susana Marcos, Alberto de Castro, Lucie Sawides). The defense will take place March 23 at 15h (CET) at Complutense University of Madrid (Facultad de Ciencias Físicas, Sala de Grados) and can also be followed remotely through Google Meet.

Evaluating the effect of ocular aberrations on the performance of a new refractive IOL using Adaptive Optics, published in Biomedical Optics Express

 

Adaptive optics (AO) visual simulators are excellent platforms for non-invasive simulation visual performance with new IOL designs, in combination with a subject own ocular aberrations and brain. In this study we measured the through focus visual acuity in subjects through a new refractive IOL physically inserted in a cuvette and projected onto the eye’s pupil, while aberrations were manipulated (corrected, or positive/negative spherical aberration added) using a deformable mirror (DM) in a custom-developed AO simulator. The IOL increased depth-of-focus (DOF) to 1.53 ± 0.21D, while maintaining high Visual Acuity, averaged across subjects and conditions and, in an experimental setting, it appears to be effective in a high range of subjects, including simulated post-LASIK subjects. 

Full reference: Carmen M. Lago, Alberto de Castro, Clara Benedí-García, Sara Aissati, and Susana Marcos, “Evaluating the effect of ocular aberrations on the simulated performance of a new refractive IOL design using adaptive optics” Biomed. Opt. Express 13, 6682-6694 (2022)

Link to the article here

Accommodation through simulated multifocal optics, published in Biomedical Optics Express

 

In this publication we use Adaptive Optics to evaluate the interaction of multifocal patterns with eye’s accommodation. Seven patterns were mapped on the spatial light modulator and the deformable mirror of an adaptive optics visual simulator, and projected onto the subjects’ eyes, representing different contact lens designs. The change in spherical aberration and the accommodative response to accommodative demands were obtained from Hartmann-Shack measurements. In summary, the present study shows that positive spherical aberration inducing conditions (CD, PSA) produced lower accommodative lag in comparison with other conditions in all the subjects. Factors such as pupil size, multifocal lens design, native aberrations of the eye, amount of spherical aberration induced should be considered in the management of myopia with MCLs and to gain insights on the mechanism of operation of these lenses. 

Full reference: Shrilekha Vedhakrishnan, Alberto de Castro, Maria Vinas, Sara Aissati and Susana Marcos “Accommodation through simulated multifocal optics,” Biomed. Opt. Express 13, 6695-6710 (2022)

Link to the article here

PhD Thesis Defense by Víctor Rodríguez López Nov 25 2022

VioBio Lab member Víctor Rodríguez López will be defending his PhD thesis, entitled “Perception of static and dynamic blur for developing clinical instrumentation in optometry and ophthalmology” (PhD supervisor: Carlos Dorronsoro). The defense will take place tomorrow Nov 25 at 3pm (CET) at Carlos III University of Madrid (Leganes Campus, Edificio Padre Soler, Aula de Grados) and can also be followed remotely through the next link: https://media.uc3m.es/live/event/6373899a8f4208e9df8b45b8

PhD Thesis Defense by Sara El Aissati on May 31 2022

VioBio Lab member Sara El Aissati Aissati will be defending her PhD thesis, entitled “Simulation and characterization of optical corrections: impact of design, monochromatic and polychromatic aberrations” (PhD supervisors: Susana Marcos & Maria Viñas). The defense will take place tomorrow May 31 at 1pm (CET) at Complutense University of Madrid (Facultad de Óptica y Óptometría, Salón de actos) and can also be followed remotely through the Google Meet Platform: https://meet.google.com/kng-qqtb-jtu

VioBio Lab at ARVO 2022 Annual Meeting

You can now check VioBio Lab contributions to ARVO 2022 Annual Meeting on OCT, corneal and scleral biomechanics, cross-linking, adaptive optics simulators, crystalline lens morphology, etc. and include them in your ARVO itinerary.

Monday, May 2

– Lupe Villegas, Fernando Zvietcovich, Alejandra Varea, Judith S. Birkenfeld, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Spatial characterization of scleral biomechanics in ex vivo rabbit eyes using multi-meridian Optical Coherence Elastography
Session Title: Refractive Error: Myopia, Hyperopia, vision and models.
Session Date/Times: May 2, 2022 from 10:00 AM to 12:00 PM.

– Andrés de la Hoz, Judith S. Birkenfeld, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Scleral deformation under air pulse – a finite element study
Session Title: Refractive Error: Myopia, Hyperopia, vision and models.
Session Date/Times: May 2, 2022 from 10:00 AM to 12:00 PM MDT

– Ana María González Ramos, Shrilekha Vedhakrishnan, Susana Marcos, Eduardo Martínez Enriquez
Presentation Type: Poster Session
Presentation Title: OCT-based quantification of multifocal contact lenses on eye
Session Title: IOLs and Presbyopia
Session Date/Times: May 2, 2022 from 12:30 PM to 2:30 PM MDT

Tuesday, May 3

– James Germann, Gaia Sardiello, Sara Otero Barros, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Nonlinear Susceptibility of Collagen fibers in Ocular Tissue with a New IR Laser Source
Session Title: Keratoconus and corneal biomechanics
Session Date/Times: May 3, 10:30 AM -12:30 PM.

– Shrilekha Vedhakrishnan, Alberto de Castro, Maria Vinas, Sara El Aissati, Susana Marcos
Presentation Type: Presenting virtually
Presentation Title: Accommodation with simulated contact lenses in Myopes
Session Title: Optics: Accommodation, Lens and Ocular Biometry
Session Date/Times: May 3, 1 PM -3 PM.

– Eduardo Martínez Enríquez, Andrea Curatolo, Judith S. Birkenfeld, Ana M. Gonzalez, Alberto de Castro, Ashik Mohamed, Marco Ruggeri, Fabrice Manns, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Estimation of the full shape of the crystalline lens from optical coherence tomography images using Eigenlenses.
Session Title: Optics: Accommodation, Lens and Ocular Biometry
Session Date/Times: May 3, 1 PM -3 PM.

– Alberto de Castro, Pilar Urizar, Eduardo Martínez-Enríquez, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Effect of fixational eye movements on OCT corneal topography measurements with raster and meridional scan patterns
Session Title: Optics: Accommodation, Lens and Ocular Biometry
Session Date/Times: May 3, 1 PM -3 PM.

– Judith Birkenfeld, Alejandra Varea, Andrea Curatolo; Ashkan Eliasy, Ana M. Gonzalez, Eduardo Martinez Enriquez, Ahmed Abass, Bernardo Lopes, Ahmed Elsheikh, Jesus Merayo-Lloves, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Corneal biomechanical parameters in healthy and early-stage keratoconus eyes from cross-meridian air-puff deformation OCT
Session Title: Keratoconus and corneal biomechanics
Session Date/Times: May 3, 2022 from 10:30 AM to 12:30 PM MDT

– Fernando Zvietcovich, Judith Birkenfeld, Alejandra Varea, Ana M. Gonzalez, Andrea Curatolo, Susana Marcos
Presentation Type: Poster Session
Presentation Title: Multi-meridian wave-based corneal optical coherence elastography in normal and keratoconic patients
Session Title: Keratoconus and corneal biomechanics
Session Date/Times: May 3, 2022 from 10:30 AM to 12:30 PM MDT

– Sara El Aissati, Palash Bharadwaj, Emily Slezak, Jiang Xiaoyun, Sierra Schleufer, Susana Marcos, Ramkumar Sabesan
Presentation Type: Poster Session
Presentation Title: Investigating the factors limiting visual acuity at different wavelengths
Session Title: Visual Function: perception, adaptation, spatial, visual acuity and binocular vision
Session Date/Times: May 3, 2022 from 10:30 AM to 12:30 PM MDT

Wednesday, May 4

– Patricia Gallego-Muñoz, Eduardo Ontoria, M. Mar Fernández Gutiérrez, Rocio Gutierrez-Contreras, Paula Olaya, Susana Marcos, M. Carmen Martínez García
Presentation Type: Poster Session
Presentation Title: Improving corneal stroma repair with Silk Fibroin-derived membranes
Session Title: Corneal Cell and Molecular Biology | Corneal Development
Session Date/Times: May 4, 2022 from 10:00 AM to 12:00 PM MDT