Author Archives: vioBioLab

VioBio Lab offers two CSIC JAE Intro Fellowships in Visual Optics and Biophotonics



CSIC has launched the JAE Intro Program, a 2-month fellowship program for Master students to gain experience in research environments.

VioBio Lab (Instituto de Óptica) will host 2 of the 100 offered fellowships, to work on Adaptive Optics Visual Simulations and High Resolution Imaging in the eye. Candidates need to have a degree in Physics, Engineering and/or Optics, a competitive CV (>7/10 average score), and a motivation to enroll in a dynamic multidisciplinary research program. Deadline for applications is May 9. The expected starting date is Sept-Oct 2017.

Reference code for the fellowships are:



Full information on the program can be found in:
Documents in English include the Summary of the call and FAQ

Interested candidates can apply directly through CSIC webpage. We recommend that candidates communicate motivation/intention by emailing


Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens published in Journal of Refractive Surgery


Is it possible to separate the wavefront aberrations of the eye from the multifocal intraocular lens pupillary power distribution after a cataract surgery? Our recent paper answers this question using OCT and LRT measurements in the case of a commercially available rotationally asymmetric segmented refractive multifocal intraocular lens, Lentis Mplus (Oculentis GmbH, Berlin, Germany). Custom analysis of ray tracing–based retinal spot diagrams allowed decoupling of the true higher order aberrations of the patient’s eye from the power pupillary distribution of the Lentis Mplus IOL, therefore providing the appropriate phase map to accurately evaluate through-focus optical quality. The method was tested using ray tracing optical simulations in a computer eye model virtually implanted with the Lentis Mplus IOL, with a generic cornea or with anterior segment geometry obtained from custom quantitative spectral-domain optical coherence tomography in a real patient. The method was applied to laser ray tracing aberrometry data at near and far fixation obtained in a patient implanted with the Lentis Mplus IOL.

Full reference: Akondi V, Pérez-Merino P, Martinez-Enriquez E, Dorronsoro C, Alejandre N, Jiménez-Alfaro I, Marcos S. Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens. J Refract Surg. 2017; 33(4): 257-265. doi: 10.3928/1081597X-20161206-03

Full article:

VioBio Lab at ARVO 2017


VioBio Lab will be present at the Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting in Baltimore (May 6-11) with 10 oral presentations and posters. Topics span: Corneal biomechanics, cross-linking, crystalline lens geometry, animal models for myopia, cataract surgery, multifocal lens simulation, chromatic aberration and accommodating IOLs.

You can find our ARVO planner itinerary in this link: VioBio ARVO Schedule

Comparison of vision through surface modulated and spatial light modulated multifocal optics published in Biomedical Optics Express

Sin título

Spatial-light-modulators (SLM) are increasingly used as active elements in adaptive optics (AO) systems to simulate optical corrections, in particular multifocal presbyopic corrections. In this study, we compared perceived visual quality with lathe-manufactured multi-zone multifocal segmented surfaces and through the same corrections simulated with a SLM in a custom-developed two-active-element AO visual simulator, and found high correspondence between them. Moreover, optical simulations predicted differences in perceived visual quality across different designs.

Full reference: Maria Vinas, Carlos Dorronsoro, Aiswaryah Radhakrishnan, Clara Benedi-García, Edward Anthony LaVilla, Jim Schwiegerling, and Susana Marcos, “Comparison of vision through surface modulated and spatial light modulated multifocal optics,” Biomed. Opt. Express 8, 2055-2068 (2017).

Biomechanical Changes After In Vivo Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA published in IOVS


Biomechanical properties of in vivo CXL rabbit corneas with two different CXL modalities were evaluated one and two months after treatments by Corvis ST air puff dynamic Scheimpflug imaging. The material properties were determined by inverse finite element analysis. Results show that CXL has higher effect after two months than one month for both CXL modalities, but it is still lower than values immediately after the treatment.

Full reference: Nandor Bekesi, Patricia Gallego-Muñoz, Lucía Ibarés-Frías, Pablo Perez-Merino, M. Carmen Martinez-Garcia, Irene E. Kochevar, Susana Marcos. “Biomechanical Changes After In Vivo Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA”. Invest. Ophthalmol. Vis. Sci. 2017;58(3):1612-1620 (2017).

Full article: 


VioBio Lab joins European Research Council 10 years Anniversary Celebrations

ERC logo

The European Research Council turns 10 years funding research excellence across Europe. VioBio Lab joins the program of celebrations in Madrid.

Susana Marcos will share experiences with ERC funding in a special session March 24  at the Ministry of Economy, Industry and Competitivity, chaired by Secretary of State of Science and Innovation Dr. Carmen Vela, and closed by the Secretary of Economy, Mr. Luis de Guindos. The Full Program of the event can be found here: Agenda ERC 10th Anniversary_ESand the Full List of Speakers here: Speakers ERC 10th Anniversary

In addition, VioBio ERC Advanced Grant Presbyopia will be featured in a temporary exhibit at the National Museum of Science and Technology, as part of an ERC weekend (March 25-26)  at the museum with a fantastic program celebrating science. Full program can be found here.

VioBio Lab ERC funding includes: 1 ERC Advanced Grant PRESBYOPIA, and 3 ERC Proof of Concept Grants OCT4IOL, SimVisSim and Light-AIOL.

New in the lab: Merche Romero and Victor Rodríguez



We welcome Merche Romero and Victor Rodríguez to VioBio Lab as Master Students from Universidad Complutense de Madrid (Facultad de Óptica y Optometría). Merche Romero has a degree in Optometry (June 2016), and large experience in clinical practice (20022015). Her MSc thesis will involve the use of adaptive optics and visual simulators in patients prior to surgery. Victor Rodriguez finished a BSc in Optometry in June of 2016 (UCM) and studies first year of Physics (UNED). His MSc thesis will involve development of monitoring systems for optotunable lenses.

OCT-based model of the guinea pig eye in vivo published in Biomedical Optics Express


A full 3-D eye model based on quantitative optical coherence tomography is presented for guinea pigs of two ages in vivo (awake and under cycloplegia). Biometric parameters obtained from OCT included cornea and lens surface elevations and radii of curvature, interocular distances, crystalline lens volume, diameter, equatorial lens position and surface area. There was a good correspondence (except for spherical aberration, likely due to the presence of GRIN) between the ocular aberrations measured with laser ray tracing and predicted from the eye model.

The study is published in Biomedical Optics Express, as part of the special issue “25 Year Anniversary of OCT”.

Full reference: Pablo Pérez-Merino, Miriam Velasco-Ocana, Eduardo Martinez-Enriquez, Luis Revuelta, Sally A McFadden, and Susana Marcos. “Three-dimensional OCT based guinea pig eye model: relating morphology and optics” Biomed. Opt. Express 8, 2173-2184 (2017).

Full article:

Susana Marcos appointed to the Scientifc Advisory Board of the Spanish Agency of Research (AEI)


The Agencia Estatal de Investigación has appointed Prof. Susana Marcos to its Scientific Advisory Board. The board is formed by a group of 12 prestigious scientists. Other scientists from CSIC included in the board are Avelino Corma, Angela Nieto, Alberto Enciso and Carme Torras.

The AEI is the Spanish research funding agency. Recently launched with a new management model, it aims at improving planning of funding of research activities.


Vision Research publishes Question-Answer format Paper on the State of the Field of Adaptive Optics

vision-researchA new paper published in the Special Issue in Vision Research on Adaptive Optics includes a revision of the technology and its applications in Vision Science, including visual psychophysics, visual simulation, retinal imaging, ocular biology and neurophysiology. The article is structured in a Question and Answer format from leaders in the field (the authors of the paper), led by the special issue guest editors Stephen A. Burns, John S. Werner and Susana Marcos.

The article is in press in Vision Research: Marcos et al.  Vision science and adaptive optics, the state of the field.  


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