Evaluating the effect of ocular aberrations on the performance of a new refractive IOL using Adaptive Optics, published in Biomedical Optics Express

 

Adaptive optics (AO) visual simulators are excellent platforms for non-invasive simulation visual performance with new IOL designs, in combination with a subject own ocular aberrations and brain. In this study we measured the through focus visual acuity in subjects through a new refractive IOL physically inserted in a cuvette and projected onto the eye’s pupil, while aberrations were manipulated (corrected, or positive/negative spherical aberration added) using a deformable mirror (DM) in a custom-developed AO simulator. The IOL increased depth-of-focus (DOF) to 1.53 ± 0.21D, while maintaining high Visual Acuity, averaged across subjects and conditions and, in an experimental setting, it appears to be effective in a high range of subjects, including simulated post-LASIK subjects. 

Full reference: Carmen M. Lago, Alberto de Castro, Clara Benedí-García, Sara Aissati, and Susana Marcos, “Evaluating the effect of ocular aberrations on the simulated performance of a new refractive IOL design using adaptive optics” Biomed. Opt. Express 13, 6682-6694 (2022)

Link to the article here

Accommodation through simulated multifocal optics, published in Biomedical Optics Express

 

In this publication we use Adaptive Optics to evaluate the interaction of multifocal patterns with eye’s accommodation. Seven patterns were mapped on the spatial light modulator and the deformable mirror of an adaptive optics visual simulator, and projected onto the subjects’ eyes, representing different contact lens designs. The change in spherical aberration and the accommodative response to accommodative demands were obtained from Hartmann-Shack measurements. In summary, the present study shows that positive spherical aberration inducing conditions (CD, PSA) produced lower accommodative lag in comparison with other conditions in all the subjects. Factors such as pupil size, multifocal lens design, native aberrations of the eye, amount of spherical aberration induced should be considered in the management of myopia with MCLs and to gain insights on the mechanism of operation of these lenses. 

Full reference: Shrilekha Vedhakrishnan, Alberto de Castro, Maria Vinas, Sara Aissati and Susana Marcos “Accommodation through simulated multifocal optics,” Biomed. Opt. Express 13, 6695-6710 (2022)

Link to the article here