Monthly Archives: April 2020
Changes of full crystalline lens shape with age, published in IOVS
Three-dimensional quantitative OCT was used to study the age-dependency of geometric parameters of the full isolated human crystalline lens, including surface radii of curvature and asphericities, lens volume, surface area, equatorial diameter and equatorial plane position. We found that most of the lens geometric parameters showed a biphasic behavior, changing rapidly before age 20 years and with a slower linear growth thereafter.
The study is the result of collaborative work between the Ophtalmic BIophysics Groups at Bascom Palmer Eye Research Institute (University of Miami), LVPrasad Eye Institute and the Visual Optics and Biophotonics Lab (Institute of Optics, CSIC).
Full reference: Eduardo Martinez-Enriquez, Alberto de Castro, Ashik Mohamed, N. Geetha Sravani, Marco Ruggeri, Fabrice Manns, Susana Marcos. Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens. Invest. Ophthalmol. Vis. Sci. 61(4):11 (2020) doi: https://doi.org/10.1167/iovs.61.4.11
Full article here
Interactions of chromatic & polychromatic aberrations published in JRS
The study measured chromatic longitudinal aberration and monochromatic aberrations at various wavelengths in patients implanted with a new monofocal intraocular lens (Clareon). We found that the effect of LCA is highest in the least aberrated eyes.
These results have interest in understanding optimal quality of the pseudophakic eyes and implications on the effect of modulating chromatic aberrations with future IOL designs. The study is a collaborative effort between VioBio Lab (IO-CSIC) and Fundación Jiménez Díaz.
Full reference: Susana Marcos, Mercedes Romero, Clara Benedí-García, Ana González-Ramos, Maria Vinas, Nicolás Alejandre, Ignacio Jiménez-Alfaro, Interaction of Monochromatic and Chromatic Aberrations in Pseudophakic Patients. Journal of Refractive Surgery. 36(4):230-238 (2020) doi:10.3928/1081597X-20200303-01
Full article here
Collagen organization after in vivo Rose Bengal/Green & Riboflavin/UVA Cross-Linking in Rabbits, published in IOVS
One option for treating keratoconus, a degenerative disease that results in a weakened cornea and vision loss, is cross-linking. Cross-linking strengthens the overall structure of the cornea by promoting the creation of covalent bonds between neighboring collagen fibrils or between fibrils and the surrounding extracellular matrix. To measure how cross-linking affects the cornea at different depths inside the stroma, three different corneal treatments were performed on rabbit animal models: no treatment, Riboflavin instillation/Ultraviolet irradiation, and Rose Bengal instillation/Green light irradiation. Rabbits were sacrificed one and two months after treatment. Images of corneal lamellae were taken with a second harmonic generation laser scanning microscopic developed at VioBio Lab and were analyzed with a MATLAB script to measure the different directions of the collagen fibers. The collagen fibers in the cross-linked corneas had more uniform fiber orientations than in untreated corneas through a depth of 300 microns. The amount of second harmonic generation is also greater in cross-linked corneas than in control corneas. Both the organization and second harmonic generation signal increased between one month and two months after treatment. This research was a collaboration between CSIC, the University of Valladolid, and the Wellman Center for Photomedicine.
Full reference: James A. Germann, Eduardo Martínez-Enríquez, M. Carmen Martínez-García, Irene E. Kochevar, Susana Marcos; Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking. Invest. Ophthalmol. Vis. Sci. 61(3):28 (2020).
Full article here
LightLens awarded the second prize of the 2019 Healthstart Madri+d Program
LightLens project has been awarded the second prize of the 4th edition of the Healthstart Madri+d program. The LightLens project is a tech transfer venture of an accommodating intraocular lens, which mimics the natural functioning of the young crystalline lens, enabled by photobonding, a VioBio Lab developed technology. The concept, prototype and demonstration of an intraocular lens capable of dynamically reshape is the result of the ERC Advanced Grant PRESBYOPIA.
Healthstart Madri+d is aimed at entrepreneurs and professionals in the healthcare sector with technological projects developed at hospitals, universities and research centers within the Madrid Region, who want to make their project a reality. The program seeks to enhance highly added value research results, throughout all the commercialization process.
VioBioLab 