Category Archives: General
In a series of interviews in Spanish Media, Prof. Susana Marcos, Director of the Visual Optics and Biophotonics Lab discusses the research work on vision, diagnostics and improvement carried at in the lab, as well as its technological and clinical impact.
Interview in Voz Pópuli, “Entrevista a Susana Marcos” by Antonio Martínez Ron: http://www.vozpopuli.com/altavoz/next/Queremos-operar-vista-cansada-miopia_0_1039996366.html
Interview in La Gaceta de Salamanca: “Un jurado con 18 Premios Nobel corona a la salmantina Susana Marcos”:
Interview in Salud Digital, “En España, la fotónica y la óptica visual tienen un prestigio superior al de muchos países”: https://consalud.es/saludigital/revista/en-espana-la-fotonica-y-la-optica-visual-tienen-un-prestigio-superior-al-de-muchos-paises-599
More press releases here: http://www.vision.csic.es/Shared%20Documents/News.aspx
Following studies on the corneal biomechanical changes induced by Rose Bengal CXL in vivo in an experimental model on rabbits, we report on the histology and clinical observations in the cornea in a 60-day follow up, in comparison with contralateral eyes left after control (de-epithealized). It was found that cell death was restricted to the anterior central stroma, and the cellular decrease did not differ significantly between RGX and DE corneas. Cell proliferation in the epithelium and stroma appeared at 2 days. In both DE and RGX corneas, recovery of the epithelium was complete at day 30, although cell repopulation of the stroma was not complete at 60 days. Rose Bengal CXL appears therefore an efficient and safe method to increase corneal stiffness, with significant advantages over traditional UV Cross-linking (use of visible light, less penetration and much faster application). The work is the result of a collaboration between Wellman Center of Photomedicine, MGH-Harvard Medical School (Irene Kochevar’s Lab), Universidad de Valladolid (Carmen Martinez’s Lab) and Instituto de Optica CSIC (VioBio Lab).
Full reference: Patricia Gallego-Muñoz; Lucía Ibares-Frías; Elvira Lorenzo; Susana Marcos; Pablo Peréz-Merino; Nandor Bekesi; Irene E. Kochevar; M. Carmen Martínez-García. Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study. Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3471-3480.
The SimVis technology to simulate multifocal corrections relies on fast tunable lenses (temporal multiplexing). We propose a method to generate and evaluate the temporal profile describing real multifocal lenses (segmented refractive, trifocal diffractive and extended depth of focus) based on the fitting of the through-focus (TF) optical quality of the multifocal component of a given multifocal lens to a linear combination of TF optical quality of monofocal lenses viable with a tunable lens. Visual Strehl ratio and TF simulated images obtained with estimated time coefficients closely matched those predicted with the M-IOL. The study also investigates the effects of temporal sampling, varying pupil size, monochromatic aberrations, longitudinal chromatic aberrations and temporal dynamics on SimVis.
Full reference: Vyas Akondi, Carlos Dorronsoro, Enrique Gambra, and Susana Marcos. “Temporal multiplexing to simulate multifocal intraocular lenses: theoretical considerations,” Biomed. Opt. Express 8, 3410-3425 (2017)
The jury of Premios Rey Jaime I, one of the most prestigious awards in Spain, announced the winners of the 2017 edition in a formal event at the Palau de la Generalitat Valenciana. Susana Marcos has received the Premio Rey Jaime I in “New Technologies” for her “important contributions to the field of the physics of vision and, in particular, her studies on imaging and ocular diagnostics that had led to the development of new intraocular lenses and the detection of ocular diseases.”
We welcome Sara El Aissati and Ana María Gonzalez-Ramos to VioBio Lab. Sara El Aissati has a degree in Optometry (2015) and a Masters in Optical Technologies by Universidad Complutense de Madrid. Ana María Gonzalez-Ramos holds a BSc in Optometry (2015) and a MSc in Optical Technologies by Universidad Complutense de Madrid. They are joining the VioBio Lab under the Comunidad de Madrid Youth Guarantee Program and will be working in the fields of adaptive optics visual simulations and characterization of the optical quality of the eye with contact and intraocular lenses.
More information about Youth Guarantee Program in the following links:
We welcome Elena Rico in VioBio Lab, joining as Project Assistant. Elena holds a BSc in Biology by Universidad Autónoma de Madrid and a MSc in Biotechnology by Aliter International Business School. Elena worked as project assistant in the European Project IS IT GREEN (Lifelong Learning Programme) and in the Madrid Biotechnology Companies Association (BioMadrid), where she gained experience in management and institutional relations.
CSIC has launched the JAE Intro Program, a 2-month fellowship program for Master students to gain experience in research environments.
VioBio Lab (Instituto de Óptica) will host 2 of the 100 offered fellowships, to work on Adaptive Optics Visual Simulations and High Resolution Imaging in the eye. Candidates need to have a degree in Physics, Engineering and/or Optics, a competitive CV (>7/10 average score), and a motivation to enroll in a dynamic multidisciplinary research program. Deadline for applications is May 9. The expected starting date is Sept-Oct 2017.
Reference code for the fellowships are:
– JAEINT17_EX_0180 (PI: DORRONSORO DIAZ, CARLOS)
– JAEINT17_EX_0188 (PI: MARCOS CELESTINO, SUSANA)
Full information on the program can be found in: https://sede.csic.gob.es/intro2017
Documents in English include the Summary of the call and FAQ
Interested candidates can apply directly through CSIC webpage. We recommend that candidates communicate motivation/intention by emailing firstname.lastname@example.org.
Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens published in Journal of Refractive Surgery
Is it possible to separate the wavefront aberrations of the eye from the multifocal intraocular lens pupillary power distribution after a cataract surgery? Our recent paper answers this question using OCT and LRT measurements in the case of a commercially available rotationally asymmetric segmented refractive multifocal intraocular lens, Lentis Mplus (Oculentis GmbH, Berlin, Germany). Custom analysis of ray tracing–based retinal spot diagrams allowed decoupling of the true higher order aberrations of the patient’s eye from the power pupillary distribution of the Lentis Mplus IOL, therefore providing the appropriate phase map to accurately evaluate through-focus optical quality. The method was tested using ray tracing optical simulations in a computer eye model virtually implanted with the Lentis Mplus IOL, with a generic cornea or with anterior segment geometry obtained from custom quantitative spectral-domain optical coherence tomography in a real patient. The method was applied to laser ray tracing aberrometry data at near and far fixation obtained in a patient implanted with the Lentis Mplus IOL.
Full reference: Akondi V, Pérez-Merino P, Martinez-Enriquez E, Dorronsoro C, Alejandre N, Jiménez-Alfaro I, Marcos S. Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens. J Refract Surg. 2017; 33(4): 257-265. doi: 10.3928/1081597X-20161206-03
Full article: http://www.healio.com/ophthalmology/journals/jrs/2017-4-33-4/%7Bd8d8f4f9-f803-4d97-8237-6d5ab9f3a928%7D/evaluation-of-the-true-wavefront-aberrations-in-eyes-implanted-with-a-rotationally-asymmetric-multifocal-intraocular-lens
VioBio Lab will be present at the Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting in Baltimore (May 6-11) with 10 oral presentations and posters. Topics span: Corneal biomechanics, cross-linking, crystalline lens geometry, animal models for myopia, cataract surgery, multifocal lens simulation, chromatic aberration and accommodating IOLs.
You can find our ARVO planner itinerary in this link: VioBio ARVO Schedule
Comparison of vision through surface modulated and spatial light modulated multifocal optics published in Biomedical Optics Express
Spatial-light-modulators (SLM) are increasingly used as active elements in adaptive optics (AO) systems to simulate optical corrections, in particular multifocal presbyopic corrections. In this study, we compared perceived visual quality with lathe-manufactured multi-zone multifocal segmented surfaces and through the same corrections simulated with a SLM in a custom-developed two-active-element AO visual simulator, and found high correspondence between them. Moreover, optical simulations predicted differences in perceived visual quality across different designs.
Full reference: Maria Vinas, Carlos Dorronsoro, Aiswaryah Radhakrishnan, Clara Benedi-García, Edward Anthony LaVilla, Jim Schwiegerling, and Susana Marcos, “Comparison of vision through surface modulated and spatial light modulated multifocal optics,” Biomed. Opt. Express 8, 2055-2068 (2017).